Description

1-Bromo-6-(Trifluoromethyl)Isoquinoline is a high-value, multi-functional heterocyclic building block. This compound is strategically important for its role in constructing complex molecular architectures, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active molecules targeting various disease pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the isoquinoline and trifluoromethyl motifs for enhanced bioactivity and stability.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Ligand Synthesis: Utilized in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Fluorinated Compound Libraries: An essential component for building diverse compound libraries in medicinal chemistry, exploring the effects of the trifluoromethyl group on pharmacokinetics.

Basic Information

Product Name	1-Bromo-6-(Trifluoromethyl)Isoquinoline
CAS No.	1196152-93-8
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	6-(Trifluoromethyl)-1-bromoisoquinoline; 1-Bromo-6-trifluoromethylisoquinoline; Isoquinoline, 1-bromo-6-(trifluoromethyl)-; 1-Bromo-6-(trifluoromethyl)isoquinoline; 1-Bromo-6-(trifluoromethyl)isoquinoline (CAS 1196152-93-8)
EINECS	Contact for details

Quality Control

Our 1-Bromo-6-(Trifluoromethyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and GC-MS analysis. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.