Description

1-Bromo-6-Fluoroisoquinoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its dual reactive sites, the bromine and fluorine substituents, which enable precise, sequential functionalization for constructing complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and anticancer agent research.
• Agrochemical Synthesis: Used to construct advanced active ingredients for crop protection products, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Building Block: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the isoquinoline core contributes to charge transport properties.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Fluorine Chemistry Research: An important substrate for studying nucleophilic aromatic substitution (SNAr) and cross-coupling reactions involving fluorinated arenes.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and target engagement.

Basic Information

Product Name	1-Bromo-6-Fluoroisoquinoline
CAS No.	1196151-59-3
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	6-Fluoro-1-bromoisoquinoline; 1-Bromo-6-fluoro-isoquinoline; Isoquinoline, 1-bromo-6-fluoro-; 6-Fluoro-1-bromoisoquinoline; 1-Bromo-6-fluoroisoquinoline; 1196151-59-3; 6-Fluoro-1-bromo-isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Bromo-6-Fluoroisoquinoline is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.