Description

Acemetacin-D4 is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) Acemetacin, where four hydrogen atoms are replaced by deuterium. This compound is a critical internal standard for the precise quantification of Acemetacin in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for pharmaceutical research and development, clinical pharmacology, and bioanalytical laboratories requiring the highest levels of accuracy and reproducibility in pharmacokinetic and metabolic studies.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the accurate measurement of Acemetacin concentrations in plasma, serum, and tissue samples via mass spectrometry.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in metabolism studies.
• Method Development and Validation: Critical for establishing and validating robust, GLP-compliant bioanalytical methods for regulatory submissions.
• Drug Impurity and Degradation Analysis: Used as a reference marker in stability-indicating assays to monitor drug purity and stability.
• Forensic and Anti-Doping Analysis: Provides definitive identification and quantification in specialized testing scenarios.

Basic Information

Product Name	Acemetacin-D4
CAS No.	1196151-16-2
Molecular Formula	C21H14D4ClNO6
Molecular Weight	407.83 g/mol (approximate)
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic-D4 acid; Acemetacin (phenyl-D4); [2,4,5,6-D4]-Acemetacin; Acemetacin-d4; Acemetacin (D4); Deuterated Acemetacin; Acemetacin Internal Standard; Stable Isotope-Labeled Acemetacin
EINECS	Contact for details

Quality Control

Every batch of Acemetacin-D4 is manufactured and tested to meet the stringent requirements of research and bioanalytical applications. Our quality assurance includes rigorous analysis for isotopic purity, chemical purity, and identity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from HPLC, NMR, and MS. We support compliance with GLP and GMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. For long-term stability, store desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.