Description

3-(5-Bromo-2,3-Dihydro-Indol-1-Yl)-Azetidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. This compound serves as a critical building block for medicinal chemists, enabling the construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly those targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Heterocyclic Compound Synthesis: Serves as a versatile scaffold for constructing complex nitrogen-containing heterocycles, which are prevalent in many drug molecules.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	3-(5-Bromo-2,3-Dihydro-Indol-1-Yl)-Azetidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1194732-22-3
Molecular Formula	C16H21BrN2O2
Molecular Weight	353.26 g/mol
Synonyms	1-(1-(tert-Butoxycarbonyl)azetidin-3-yl)-5-bromo-2,3-dihydro-1H-indole; tert-Butyl 3-(5-bromo-2,3-dihydro-1H-indol-1-yl)azetidine-1-carboxylate; 5-Bromo-1-[1-(tert-butoxycarbonyl)azetidin-3-yl]indoline; 3-(5-Bromoindolin-1-yl)azetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-(5-bromo-2,3-dihydro-1H-indol-1-yl)-, 1,1-dimethylethyl ester; BOC-Protected 3-(5-Bromoindolin-1-yl)azetidine
EINECS	Contact for details

Quality Control

Our production of 3-(5-Bromo-2,3-Dihydro-Indol-1-Yl)-Azetidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Every batch is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring traceability and reliability for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.