Description

5,7-Dichloro-2-Trityl-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique tetrahydroisoquinoline scaffold. This compound is of significant value in medicinal chemistry for the synthesis of complex bioactive molecules, particularly as a key building block in drug discovery programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, where precise chemical structure and reliable purity are critical for successful outcomes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting the central nervous system.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• API Synthesis: Employed in the development and scale-up processes for Active Pharmaceutical Ingredients (APIs) with tetrahydroisoquinoline cores.
• Chemical Biology Probes: Acts as a starting material for creating specialized probes used to study biological pathways and protein interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for synthetic methodology development and pharmacological studies.

Basic Information

Product Name	5,7-Dichloro-2-Trityl-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid
CAS No.	1194550-56-5
Molecular Formula	C29H23Cl2NO2
Molecular Weight	488.41 g/mol
Synonyms	5,7-Dichloro-2-triphenylmethyl-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid; 2-Trityl-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; 5,7-Dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; DTTHIQ-6-COOH; CAS 1194550-56-5
EINECS	Contact for details

Quality Control

Our 5,7-Dichloro-2-Trityl-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry-standard analytical protocols to guarantee the material meets the specifications required for pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.