Description

4-Iodo-1-Methyl-3-Trifluoromethyl-1H-Pyrazole is a high-value, halogenated pyrazole derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both iodine and trifluoromethyl groups, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazole core and halogen substituents.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form carbon-carbon bonds.
• Fluorine Chemistry: The trifluoromethyl group is integral for modulating lipophilicity, metabolic stability, and bioavailability in drug design.
• Chemical Biology: Utilized as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.

Basic Information

Product Name	4-Iodo-1-Methyl-3-Trifluoromethyl-1H-Pyrazole
CAS No.	1194377-09-7
Molecular Formula	C5H4F3IN2
Molecular Weight	291.00 g/mol
Synonyms	1-Methyl-4-iodo-3-(trifluoromethyl)-1H-pyrazole; 4-Iodo-1-methyl-3-(trifluoromethyl)pyrazole; 3-Trifluoromethyl-4-iodo-1-methylpyrazole; 1-Methyl-3-trifluoromethyl-4-iodopyrazole; 4-Iodo-1-methyl-3-trifluoromethylpyrazole; Pyrazole, 4-iodo-1-methyl-3-(trifluoromethyl)-; 1194377-09-7 (CAS)
EINECS	Contact for details

Quality Control

Our 4-Iodo-1-Methyl-3-Trifluoromethyl-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.