Description

4-Bromo-2-(Trifluoromethyl)Thiophene is a high-value, multi-functional halogenated heterocyclic building block. This compound is engineered to serve as a critical precursor in advanced organic synthesis, offering a unique combination of bromine and trifluoromethyl substituents on a thiophene core for precise molecular modifications. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries seeking to introduce specific functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Organic Electronic Materials: Serves as a building block for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and photovoltaic cells.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis, facilitating challenging cross-coupling reactions.
• Fluorinated Compound Research: An invaluable reagent for introducing fluorine-containing motifs into target structures to alter physicochemical properties like lipophilicity and bioavailability.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring high-purity, specialized brominated thiophene derivatives.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Thiophene
CAS No.	1194374-08-7
Molecular Formula	C5H2BrF3S
Molecular Weight	230.03 g/mol
Synonyms	2-(Trifluoromethyl)-4-bromothiophene; 4-Bromo-2-trifluoromethylthiophene; Thiophene, 4-bromo-2-(trifluoromethyl)-; 4-Bromo-α,α,α-trifluoro-2-thiophenemethane
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-(Trifluoromethyl)Thiophene is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the rigorous standards required for research and scale-up. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by GC/HPLC and NMR is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.