Description

Metaxalone‐D3 CAS NO 1192812-66-0 is a deuterium-labeled analog of the centrally acting skeletal muscle relaxant, Metaxalone. This stable isotope-labeled compound is essential for advanced analytical and research applications where precise quantification and metabolic tracking are required. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and bioanalytical studies.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of Metaxalone in biological matrices.
• Critical for conducting pharmacokinetic and metabolism studies (ADME) to understand the drug's absorption, distribution, metabolism, and excretion profile.
• Facilitates bioanalytical method development and validation in compliance with regulatory guidelines (e.g., FDA, EMA).
• Enables doping control analysis in forensic and sports anti-doping laboratories.
• Supports clinical research and therapeutic drug monitoring (TDM) programs.
• Employed in stable isotope dilution assays to ensure high precision and accuracy in analytical measurements.
• Used for impurity profiling and reference standard qualification in pharmaceutical quality control.

Basic Information

Product Name	Metaxalone‐D3
CAS No.	1192812-66-0
Molecular Formula	C12H12D3NO3
Molecular Weight	222.27 g/mol (approximate)
Synonyms	5-[(3,5-Dimethylphenoxy)methyl]-2-oxazolidinone-d3; Metaxalone (phenyl-d3); Metaxalone-d3; SKF-5137-d3; 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-, labeled with deuterium; Deuterated Metaxalone; Metaxalone Internal Standard
EINECS	Contact for details

Quality Control

Our Metaxalone‐D3 is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic tests, including NMR for deuterium incorporation and HPLC for chemical purity. We support cGMP and ISO 9001 compliant processes for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.