Description

4-Ethynyl-1H-Indole-2,3-Dione is a high-purity, functionalized isatin derivative characterized by its reactive ethynyl group. This compound serves as a versatile and critical advanced pharmaceutical intermediate for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly for targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Organic Synthesis Reagent: Used in click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) and Sonogashira cross-coupling reactions to introduce the ethynyl-indole moiety.
• Agrochemical Research: Serves as a precursor for developing new active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Investigated as a monomer or functional additive for creating specialized polymers and advanced organic materials.
• Biochemical Probe Development: Used to create labeled compounds or affinity probes for studying biological pathways and protein interactions.

Basic Information

Product Name	4-Ethynyl-1H-Indole-2,3-Dione
CAS No.	1192263-97-0
Molecular Formula	C10H5NO2
Molecular Weight	171.15 g/mol
Synonyms	4-Ethynylisatin; 4-Ethynyl-1H-indole-2,3-dione; 4-Ethynyl-2,3-dihydro-2,3-dioxoindole; 4-Ethynyl-2,3-dioxoindoline; Isatin, 4-ethynyl-; 1192263-97-0; 4-Ethynylindoline-2,3-dione
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-1H-Indole-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.