Description

5-Bromo-1-Methyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-value, synthetically versatile indole-based boronic ester building block. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures in modern organic synthesis. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in creating complex heterocyclic cores for oncology and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Academic & Contract Research: A critical reagent for methodology development and complex molecule synthesis in university and CRO laboratories.
• Scale-up Process Chemistry: Suitable for optimization and pilot-scale synthesis, bridging the gap between discovery and commercial manufacturing.

Basic Information

Product Name	5-Bromo-1-Methyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	1192037-87-8
Molecular Formula	C15H19BBrNO2
Molecular Weight	336.04 g/mol
Synonyms	5-Bromo-1-methyl-1H-indole-2-boronic acid pinacol ester; 2-(5-Bromo-1-methyl-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Bromo-1-methylindole-2-boronic acid pinacol ester; 1-Methyl-5-bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 5-Bromo-1-methyl-2-(pinacolboron)-1H-indole; 5-Bromo-1-methyl-2-boronic acid pinacol ester indole
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Methyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.