Description

5-Borono-3-Methylthiophene-2-Carboxylic Acid CAS NO 1190830-77-3 is a high-value, multi-functional heterocyclic building block containing both boronic acid and carboxylic acid functional groups. This unique bifunctional structure makes it a critical intermediate for constructing complex molecules via cross-coupling and condensation reactions. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides, leveraging its boronic acid group for creating diverse biaryl structures.
• Material Science: Serves as a precursor for functionalized polymers and organic electronic materials due to its conjugated thiophene core and reactive handles.
• Chemical Biology & Proteomics: Employed as a tool compound or linker in the synthesis of activity-based probes and bioconjugates.
• Ligand Synthesis: Useful for preparing chelating ligands in catalysis, where the carboxylic acid can coordinate to metals.
• Academic & Contract Research: A versatile reagent for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	5-Borono-3-Methylthiophene-2-Carboxylic Acid
CAS No.	1190830-77-3
Molecular Formula	C7H7BO4S
Molecular Weight	197.99 g/mol
Synonyms	3-Methyl-5-boronothiophene-2-carboxylic acid; 2-Carboxy-3-methyl-5-thiopheneboronic acid; 5-Borono-3-methyl-2-thiophenecarboxylic acid; (3-Methyl-2-carboxythiophen-5-yl)boronic acid; 5-Boron-3-methylthiophene-2-carboxylic acid; B-[3-Methyl-2-(carboxy)thien-5-yl]boronic acid; 3-Methylthiophene-5-boronic acid-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-Borono-3-Methylthiophene-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.