Description

3-Formyl-4-Azaindole-6-Carboxylic Acid Methyl Ester is a high-purity, heterocyclic organic building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical synthetic intermediate for constructing complex molecular architectures, particularly in the creation of kinase inhibitors and other targeted therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for lead optimization and scalable synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel kinase inhibitors (e.g., JAK, ALK, EGFR inhibitors) for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Versatile scaffold for structure-activity relationship (SAR) studies and lead compound diversification.
• Process Chemistry: Used in the development and scale-up of active pharmaceutical ingredient (API) manufacturing routes.
• Bioconjugation & Probe Development: The formyl group enables site-specific conjugation for creating chemical probes and antibody-drug conjugates (ADCs).
• Agrochemical Research: Intermediate in the discovery of new herbicides and fungicides with novel modes of action.
• Material Science: Potential building block for organic electronic materials and advanced polymers.

Basic Information

Product Name	3-Formyl-4-Azaindole-6-Carboxylic Acid Methyl Ester
CAS No.	1190322-90-7
Molecular Formula	C10H8N2O3
Molecular Weight	204.18 g/mol
Synonyms	Methyl 3-formyl-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; 1H-Pyrrolo[3,2-b]pyridine-6-carboxylic acid, 3-formyl-, methyl ester; 3-Formyl-1H-pyrrolo[3,2-b]pyridine-6-carboxylic acid methyl ester; 4-Azaindole-6-carboxylic acid, 3-formyl-, methyl ester; 6-Methoxycarbonyl-1H-pyrrolo[3,2-b]pyridine-3-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 3-Formyl-4-Azaindole-6-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.