Description

3-Amino-7-Azaindole-5-Carboxylic Acid Methyl Ester is a high-value, heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its functionalized azaindole scaffold, which serves as a privileged structure for modulating biological activity and physicochemical properties in drug discovery. This compound is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of novel therapeutic agents, particularly kinase inhibitors and other small molecule drugs targeting challenging disease pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel kinase inhibitors, particularly for oncology and inflammatory disease targets.
• Medicinal Chemistry Scaffold: Used as a versatile core structure for SAR (Structure-Activity Relationship) studies and lead optimization programs due to its hydrogen bonding capabilities and planar aromatic system.
• Chemical Biology Probe Synthesis: Employed in the construction of molecular probes for studying enzyme function and cellular signaling pathways.
• Fine Chemical Synthesis: Serves as a specialized building block for the multi-step synthesis of complex heterocyclic compounds and functional materials.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	3-Amino-7-Azaindole-5-Carboxylic Acid Methyl Ester
CAS No.	1190322-62-3
Molecular Formula	C9H9N3O2
Molecular Weight	191.19 g/mol
Synonyms	Methyl 3-amino-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 3-Amino-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; 5-(Methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-amine; 7-Azaindole-5-carboxylic acid, 3-amino-, methyl ester; 3-Amino-7-azaindole-5-methyl carboxylate
EINECS	Contact for details

Quality Control

Our 3-Amino-7-Azaindole-5-Carboxylic Acid Methyl Ester is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems support development under cGMP guidelines as required for advanced non-GMP and GMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.