Description

4-Methyl-3-Nitro-5-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique azaindole scaffold. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel, small-molecule drug candidates, particularly in oncology and kinase inhibitor research. It is primarily required by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted therapeutic agents, especially kinase inhibitors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Used in the development of chemical probes to study specific biological pathways and protein functions.
• Agrochemical Research: Potential application as an intermediate in the development of new active ingredients for crop protection.
• Academic Research: Utilized in universities and research institutes for organic synthesis methodology development and heterocyclic chemistry studies.

Basic Information

Product Name	4-Methyl-3-Nitro-5-Azaindole
CAS No.	1190319-83-5
Molecular Formula	C8H7N3O2
Molecular Weight	177.16 g/mol
Synonyms	3-Nitro-4-methyl-7-azaindole; 4-Methyl-3-nitro-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-methyl-3-nitro-; 4-Methyl-3-nitro-1H-pyrrolo[2,3-b]pyridine; 3-Nitro-4-methyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-Nitro-5-Azaindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.