Description

6-Cyano-3-Iodo-7-Azaindole is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring a cyano group, a halogen atom, and a nitrogen-rich azaindole core, makes it a versatile intermediate for constructing complex pharmacophores. This compound is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibition.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of small molecule drug candidates, especially in oncology and CNS research.
• Kinase Inhibitor Scaffold: Used to build core structures for potential protein kinase inhibitors due to the azaindole motif's affinity for ATP-binding sites.
• Agrochemical Research: Serves as a building block for developing new active ingredients with herbicidal or insecticidal properties.
• Material Science Precursor: Potential use in creating organic electronic materials or ligands for catalytic systems.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aryl or alkynyl groups.
• Chemical Biology Probes: Can be used to develop molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	6-Cyano-3-Iodo-7-Azaindole
CAS No.	1190318-91-2
Molecular Formula	C8H4IN3
Molecular Weight	285.04 g/mol
Synonyms	3-Iodo-7-azaindole-6-carbonitrile; 1H-Pyrrolo[2,3-b]pyridine-6-carbonitrile, 3-iodo-; 3-Iodo-1H-pyrrolo[2,3-b]pyridine-6-carbonitrile; 6-Cyano-3-iodo-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-6-cyano-7-azaindole; 7-Azaindole-6-carbonitrile, 3-iodo- derivative
EINECS	Contact for details

Quality Control

Every batch of 6-Cyano-3-Iodo-7-Azaindole is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.