Description

7-Hydroxy-3-Iodo-4-Azaindole is a high-purity, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a reactive iodine substituent with a hydroxylated azaindole scaffold, making it an essential precursor for constructing complex pharmacophores. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of advanced candidates for new herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a building block for organic electronic materials, such as charge-transport layers or light-emitting components.
• Chemical Biology: Employed as a molecular probe or a tagged ligand in biochemical assays and target identification studies.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Library Synthesis: A valuable starting material for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	7-Hydroxy-3-Iodo-4-Azaindole
CAS No.	1190318-75-2
Molecular Formula	C7H5IN2O
Molecular Weight	260.03 g/mol
Synonyms	3-Iodo-7-hydroxy-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-1H-pyrrolo[2,3-b]pyridin-7-ol; 7-Hydroxy-3-iodo-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-7-azaindol-7-ol; 4-Azaindole, 7-hydroxy-3-iodo-; 7-Hydroxy-3-iodo-4-azaindole; Building block 1190318-75-2
EINECS	Contact for details

Quality Control

Our 7-Hydroxy-3-Iodo-4-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its light-sensitive and easily oxidized nature, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.