Description

3-Nitro-7-Azaindole-4-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its nitro-substituted azaindole core. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel drug candidates. It is primarily needed by R&D laboratories and pharmaceutical manufacturers focused on developing targeted small-molecule therapies, particularly in oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for drug discovery programs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Kinase Inhibitor Development: Serves as a core structural element in the design and synthesis of potential kinase inhibitors.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.
• Academic Research: Used in university and institutional labs for exploratory research in organic and bioorganic chemistry.

Basic Information

Product Name	3-Nitro-7-Azaindole-4-Carboxylic Acid Methyl Ester
CAS No.	1190314-11-4
Molecular Formula	C9H7N3O4
Molecular Weight	221.17 g/mol
Synonyms	Methyl 3-nitro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 3-nitro-, methyl ester; 3-Nitro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester; 7-Azaindole-4-carboxylic acid, 3-nitro-, methyl ester; Methyl 3-nitro-7-azaindole-4-carboxylate
EINECS	Contact for details

Quality Control

Our 3-Nitro-7-Azaindole-4-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.