Description

5-Bromo-3-Iodo-4-Methyl-7-Azaindole is a high-purity, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring both bromine and iodine atoms on the azaindole scaffold, makes it a versatile intermediate for constructing complex molecules via cross-coupling reactions. Pharmaceutical and agrochemical R&D teams need it for developing new active ingredients, particularly in medicinal chemistry where the 7-azaindole core is a privileged pharmacophore. Its precise halogenation pattern allows for selective functionalization, enabling the rapid exploration of chemical space in drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Serves as a precursor for organic electronic materials, such as OLED emitters and charge transport layers.
• Chemical Biology: Employed in the creation of molecular probes and labeled compounds for studying biological pathways.
• Cross-Coupling Reactions: The bromine and iodine substituents act as orthogonal handles for sequential Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Library Synthesis: An essential scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Item	Detail
Product Name	5-Bromo-3-Iodo-4-Methyl-7-Azaindole
CAS No.	1190313-99-5
Molecular Formula	C8H6BrIN2
Molecular Weight	352.96 g/mol
Synonyms	4-Methyl-5-bromo-3-iodo-7-azaindole; 5-Bromo-3-iodo-4-methyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-4-methyl-; 5-Br-3-I-4-Me-7-azaindole; 4-Methyl-5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine; 7-Azaindole, 5-bromo-3-iodo-4-methyl-
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodo-4-Methyl-7-Azaindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive R&D and scale-up processes. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available with every shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.