Description

4-(Trifluoromethyl)-5-Azaindole-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for modern pharmaceutical and agrochemical research. This compound matters because its unique molecular scaffold, featuring both a trifluoromethyl group and an azaindole core, is critical for modulating the biological activity, metabolic stability, and physicochemical properties of advanced small molecules. It is primarily needed by medicinal chemists and R&D teams in the pharmaceutical industry for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas, as well as in the development of next-generation crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug-like properties.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the azaindole moiety.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and advanced polymers due to its conjugated system.

Basic Information

Product Name	4-(Trifluoromethyl)-5-Azaindole-3-Carboxylic Acid
CAS No.	1190313-29-1
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	4-(Trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid; 5-Azaindole-3-carboxylic acid, 4-(trifluoromethyl)-; 1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid, 4-(trifluoromethyl)-; 4-Trifluoromethyl-5-aza-indole-3-carboxylic acid; 4-Trifluoromethyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid; 4-CF3-5-azaindole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-5-Azaindole-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material is suitable for use in regulated pre-clinical and discovery phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.