Description

4-Fluoro-5-Aza-2-Oxindole is a high-value, fluorinated heterocyclic building block of significant interest in modern medicinal chemistry. Its core structure, featuring both a fluorinated indole and oxindole moiety, makes it a privileged scaffold for designing novel bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of targeted libraries and potential drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, particularly targeting cancer and inflammatory diseases.
• Medicinal Chemistry Research: Used as a core scaffold in fragment-based drug discovery (FBDD) and high-throughput screening (HTS) campaigns to explore new chemical space.
• Agrochemical Synthesis: Serves as a building block for novel herbicides and pesticides, leveraging the biological activity of the fluorinated oxindole structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Organic Synthesis: Acts as a versatile precursor for further functionalization, enabling the creation of complex heterocyclic compounds.

Basic Information

Product Name	4-Fluoro-5-Aza-2-Oxindole
CAS No.	1190312-66-3
Molecular Formula	C7H3FN2O2
Molecular Weight	166.11 g/mol
Synonyms	4-Fluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 4-Fluoro-5-azaoxindole; 4-Fluoro-5-aza-2-oxindole; 1H-Pyrrolo[2,3-b]pyridin-2(3H)-one, 4-fluoro-; 4-Fluoro-3,5-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 4-Fluoro-5-azaindolin-2-one; 4-Fluoro-5-aza-1H-indol-2-one
EINECS	Contact for details

Quality Control

Our 4-Fluoro-5-Aza-2-Oxindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards for the production of pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.