Description

3-Chloro-5-Trifluoromethyl-4-Azaindole is a high-value, halogenated azaindole derivative, a crucial building block in modern pharmaceutical and agrochemical research. Its molecular architecture, featuring both chloro and trifluoromethyl substituents on the azaindole scaffold, makes it an indispensable intermediate for creating novel bioactive compounds. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of kinase inhibitors and other targeted therapies, as well as in agrochemical research for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of kinase inhibitors (e.g., JAK, BTK inhibitors) and other small molecule drug candidates.
• Agrochemical Synthesis: Used in the discovery and production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the azaindole core.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study enzyme function and signal transduction pathways.
• Material Science Research: Potential precursor for specialty chemicals and advanced organic electronic materials due to its unique electronic properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for client projects.

Basic Information

Product Name	3-Chloro-5-Trifluoromethyl-4-Azaindole
CAS No.	1190312-01-6
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 3-Chloro-5-(trifluoromethyl)-4-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 3-chloro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-chloro-1H-pyrrolo[2,3-b]pyridine; 3-Chloro-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Trifluoromethyl-4-Azaindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.