Description

3-Amino-6-Trifluoromethyl-4-Azaindole is a high-value, multi-functional heterocyclic building block distinguished by its unique trifluoromethyl and amino-substituted azaindole scaffold. This compound is critical for medicinal chemistry research, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon for the design and synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization programs to explore structure-activity relationships (SAR) and improve drug-like properties.
• Agrochemical Development: Serves as a building block for creating novel active ingredients with potential herbicidal or insecticidal activity.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential precursor for advanced organic electronic materials due to its electron-deficient aromatic system.

Basic Information

Product Name	3-Amino-6-Trifluoromethyl-4-Azaindole
CAS No.	1190311-51-3
Molecular Formula	C8H6F3N3
Molecular Weight	201.15 g/mol
Synonyms	3-Amino-6-(trifluoromethyl)-1H-pyrrolo[3,2-c]pyridine; 6-(Trifluoromethyl)-1H-pyrrolo[3,2-c]pyridin-3-amine; 3-Amino-6-trifluoromethyl-1H-pyrrolo[3,2-c]pyridine; 4-Azaindole, 3-amino-6-(trifluoromethyl)-; 3-Amino-6-trifluoromethyl-4-aza-indole
EINECS	Contact for details

Quality Control

Our 3-Amino-6-Trifluoromethyl-4-Azaindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity, the material should be stored under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.