Description

Adefovir-D4 CAS NO 1190021-70-5 is a deuterated analog of the antiviral drug Adefovir, serving as a critical stable isotope-labeled internal standard for precise bioanalytical quantification. This high-purity compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies in pharmaceutical research and development. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the development and quality control of antiviral therapeutics.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Quantification of Adefovir and its metabolites in pharmacokinetic (PK) and bioequivalence studies.
• Supporting drug metabolism and disposition (DMPK) research for antiviral drug candidates.
• Ensuring data integrity in regulatory submissions to agencies like the FDA and EMA.
• Quality control and method validation in pharmaceutical manufacturing environments.
• Use in specialized clinical research for monitoring drug levels in patient samples.

Basic Information

Product Name	Adefovir-D4
CAS No.	1190021-70-5
Molecular Formula	C8H8D4N5O4P
Molecular Weight	279.20 g/mol (for monoisotopic mass)
Synonyms	9-[2-[[Bis[(2,2,2-trifluoroethoxy)phosphinyl]methoxy]ethyl]adenine-d4; PMEA-d4; GS 0393-d4; Bis(POM)PMEA-d4; Adefovir Dipivoxil Impurity D4; Deuterated Adefovir; Adefovir Internal Standard; [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic Acid-d4
EINECS	Contact for details

Quality Control

Every batch of Adefovir-D4 is manufactured and tested under strict quality management systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing detailed results for isotopic enrichment, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.