Description

tert-Butyl-D9 4-Nitrophenyl Carbonate is a deuterated chemical reagent featuring a carbonate ester linkage activated by a 4-nitrophenoxy leaving group. This compound is specifically designed for the efficient and selective introduction of the tert-butyloxycarbonyl (Boc-D9) protecting group onto amines, alcohols, and other nucleophiles under mild conditions. It is an essential tool for researchers and manufacturers in pharmaceutical development, proteomics, and advanced organic synthesis, particularly for applications requiring isotopic labeling, metabolic studies, or enhanced analytical detection.

Application

• Deuterated Boc-Protecting Reagent: For the synthesis of Boc-D9-protected amino acids, peptides, and other sensitive intermediates in labeled compound production.
• Isotope-Labeled API Synthesis: A key building block in the development of deuterated active pharmaceutical ingredients (APIs) for drug discovery and metabolic research.
• Proteomics & Mass Spectrometry: Used in chemical proteomics for labeling strategies that enhance detection and quantification via mass spectrometry.
• Organic Synthesis Intermediate: Serves as a versatile reagent for introducing the tert-butyl carbonate moiety in complex molecule construction.
• Polymer & Material Science: Can be utilized in the surface functionalization of materials or the synthesis of specialized polymers requiring protected functional groups.
• Standards & Calibrants Manufacturing: For producing high-purity, isotopically labeled internal standards used in analytical chemistry.

Basic Information

Item	Detail
Product Name	tert-Butyl-D9 4-Nitrophenyl Carbonate
CAS No.	1190006-35-9
Molecular Formula	C11H2D9NO5
Molecular Weight	Contact for details
Synonyms	(tert-Butyl-d9) (4-nitrophenyl) carbonate; Boc-D9 4-Nitrophenyl Carbonate; 4-Nitrophenyl tert-Butyl-d9 Carbonate; tert-Butoxy-d9-carbonyl 4-nitrophenyl ester; Deuterated Boc-ONp; Perdeuterated tert-Butyl 4-Nitrophenyl Carbonate; 4-Nitrophenyl N-(tert-butoxy-d9-carbonyl)oxyamine; Carbonoperoxoic acid, 2-methyl-2-(trideuteriomethyl-d6)propyl-d3 ester, 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl-D9 4-Nitrophenyl Carbonate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, isotopic enrichment, and batch-to-batch consistency. A Certificate of Analysis (COA) is provided, detailing specifications such as purity (by HPLC/NMR), deuterium enrichment, and identification. We support cGMP and ISO compliant manufacturing for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Deuterium Enrichment	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.