Description

11-[3-(Trideuteriomethylamino)Propyl]-5,6-Dihydrobenzo[B][1]Benzazepin-3-Ol is a deuterated derivative of a benzazepine scaffold, representing a high-value advanced pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly for creating novel drug candidates with enhanced metabolic stability and pharmacokinetic profiles. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on deuterium-enabled drug discovery and development.

Application

• Deuterated Drug Development: Serves as a key building block for synthesizing deuterium-labeled pharmaceutical compounds, where the trideuteriomethyl group can improve metabolic stability.
• Metabolic Pathway Tracer: Used in pharmacological research as a stable isotope-labeled tracer to study drug metabolism and distribution in vivo.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Medicinal Chemistry Research: Provides a versatile intermediate for the synthesis of novel benzazepine-based molecules targeting central nervous system (CNS) disorders.
• Isotope Effect Studies: Enables fundamental research into kinetic isotope effects (KIE) for optimizing reaction pathways in synthetic chemistry.

Basic Information

Product Name	11-[3-(Trideuteriomethylamino)Propyl]-5,6-Dihydrobenzo[B][1]Benzazepin-3-Ol
CAS No.	1189998-63-7
Molecular Formula	C20H24D3NO
Molecular Weight	298.43 g/mol
Synonyms	11-[3-(Trideuteriomethylamino)propyl]-5,6-dihydro-11H-benzo[b][1]benzazepin-3-ol; Deuterated Benzazepinol; 11-(3-((Methyl-d3)amino)propyl)-5,6-dihydrobenzo[b][1]benzazepin-3-ol; 11-[3-(Trideuteriomethylamino)propyl]-5,6-dihydro-11H-benzo[b][1]benzazepin-3-ol; 1189998-63-7; 11H-Benzo[b][1]benzazepin-3-ol, 5,6-dihydro-11-[3-[(methyl-d3)amino]propyl]-; Deuterium-labeled Benzazepine Derivative
EINECS	Contact for details

Quality Control

Our production of 11-[3-(Trideuteriomethylamino)Propyl]-5,6-Dihydrobenzo[B][1]Benzazepin-3-Ol adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized and tested to ensure high chemical purity, isotopic enrichment, and structural identity. Comprehensive analytical data, including HPLC, NMR, and MS, are documented. Certificates of Analysis (COA) detailing purity, assay, and isotopic purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its light-sensitive nature, the material should be handled under appropriate conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere to mitigate potential oxidation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.