Description

5-Methyl-n-[2,3,5,6-Tetradeuterio-4-(Trifluoromethyl)Phenyl]-1,2-Oxazole-4-Carboxamide is a deuterated derivative of a key oxazole-based pharmaceutical intermediate. This compound is specifically engineered to serve as a stable isotope-labeled internal standard, providing critical support for advanced analytical and metabolic studies. It is primarily utilized by research and development laboratories in the pharmaceutical and agrochemical sectors, where precise quantification and metabolic pathway elucidation are paramount.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Essential for accurate quantitative analysis in bioanalytical method development and validation.
• Metabolite Identification and Pharmacokinetic Studies: Used to track and quantify drug metabolites in complex biological matrices.
• Drug Discovery and Development: Supports ADME (Absorption, Distribution, Metabolism, Excretion) profiling of lead compounds containing the oxazole-carboxamide scaffold.
• Isotope Dilution Analysis: Improves accuracy and precision in the measurement of target analytes in environmental or clinical samples.
• Reference Material for Regulatory Submissions: Provides the high-quality, characterized material required for FDA and EMA regulatory filings.
• Chemical Biology Research: Acts as a tool compound for mechanistic studies involving target engagement and pathway analysis.

Basic Information

Product Name	5-Methyl-n-[2,3,5,6-Tetradeuterio-4-(Trifluoromethyl)Phenyl]-1,2-Oxazole-4-Carboxamide
CAS No.	1189987-23-2
Molecular Formula	C12H5D4F3N2O2
Molecular Weight	274.22 g/mol
Synonyms	5-Methyl-N-[2,3,5,6-tetradeutero-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; 5-Methyl-N-[2,3,5,6-d4-4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide; Deuterated Oxazole Carboxamide; [2H4]-Labeled Oxazole Derivative; 1189987-23-2; 5-Methyl-N-(2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry, to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.