Description

Glyburide-D11 is a deuterium-labeled analog of the widely used second-generation sulfonylurea antidiabetic agent, glyburide. This stable isotope-labeled compound is an essential internal standard for the precise quantification and pharmacokinetic studies of glyburide in biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers engaged in drug metabolism and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Serves as a critical reference compound in the quantitative LC-MS/MS analysis of glyburide in plasma, serum, and other biological samples.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in mass spectrometry-based assays to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of glyburide.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables accurate measurement of glyburide concentrations in patient samples for clinical trial support and personalized medicine approaches.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or related substances in drug substance and product analysis.
• Stable Isotope Dilution Assay (SIDA): Employed in this highly accurate quantitative method to correct for analyte loss during sample preparation and matrix effects in mass spectrometry.

Basic Information

Product Name	Glyburide-D11
CAS No.	1189985-02-1
Molecular Formula	C23H17D11ClN3O5S
Molecular Weight	508.06 g/mol (approximate)
Synonyms	Glibenclamide-D11; 1-[4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl]-3-cyclohexyl-(phenyl-D5, cyclohexyl-D11)-urea; Deuterated Glyburide; Glyburide (phenyl-D5, cyclohexyl-D11); N-[4-[β-(2-Methoxy-5-chlorobenzamido)ethyl]benzenesulfonyl]-N′-(cyclohexyl-D11)-(phenyl-D5)urea
EINECS	Contact for details

Quality Control

Every batch of Glyburide-D11 is manufactured and analyzed under strict quality protocols to ensure the highest standards of isotopic purity and chemical identity required for sensitive mass spectrometry applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 99.0 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.