Description

1-(3'-Chlorosulfonyl-4'-Methoxyphenyl)-1-Propanone-Methyl-D3 is a high-purity, deuterated organic intermediate of significant importance in advanced chemical synthesis. This compound is valued for its role in the development of isotopically labeled molecules, which are critical for research in analytical chemistry and pharmacology. It is primarily sought after by manufacturers and research institutions engaged in the production of deuterated standards, active pharmaceutical ingredients (APIs), and novel chemical entities for metabolic and pharmacokinetic studies.

Application

• Deuterated Internal Standards: Serves as a key building block for synthesizing isotopically labeled standards used in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for precise quantitative analysis.
• Pharmaceutical Research & Development: Used as an advanced intermediate in the synthesis of deuterated drug candidates, where the incorporation of deuterium can alter metabolic pathways and improve pharmacokinetic profiles.
• Metabolite Synthesis: Facilitates the preparation of labeled metabolites for use in drug metabolism and disposition (DMPK) studies.
• Organic Synthesis Reagent: Acts as a specialized reagent in organic synthesis, particularly in reactions where the chlorosulfonyl group offers a handle for further functionalization.
• Chemical Reference Material: Employed as a high-purity reference compound in analytical laboratories for method development and validation.

Basic Information

Product Name	1-(3'-Chlorosulfonyl-4'-Methoxyphenyl)-1-Propanone-Methyl-D3
CAS No.	1189984-41-5
Molecular Formula	C11H10D3ClO4S
Molecular Weight	291.76 g/mol
Synonyms	1-Propanone, 1-[3-(chlorosulfonyl)-4-methoxyphenyl]-, methyl-d3; 1-(3-Chlorosulfonyl-4-methoxyphenyl)-1-propanone-methyl-d3; Deuterated 1-(3'-Chlorosulfonyl-4'-methoxyphenyl)propiophenone; 4-Methoxy-3-(chlorosulfonyl)propiophenone-methyl-d3; [Methyl-d3]-1-(3-chlorosulfonyl-4-methoxyphenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 1-(3'-Chlorosulfonyl-4'-Methoxyphenyl)-1-Propanone-Methyl-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical and isotopic purity, meeting the stringent requirements for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.