Description

Mono-Ethyl Malonate-1,2,3-13C3 is a stable isotope-labeled analog of mono-ethyl malonate, where all three carbon atoms in the malonate core are the carbon-13 isotope. This compound is a critical building block for the synthesis of complex molecules with isotopic labels, enabling precise tracking and quantification in metabolic and pharmacokinetic studies. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors who require high-fidelity isotopic tracers for analytical and diagnostic applications.

Application

• Pharmaceutical Research: Synthesis of carbon-13 labeled active pharmaceutical ingredients (APIs) and intermediates for use in Drug Metabolism and Pharmacokinetics (DMPK) studies and clinical trials.
• Metabolomics & Biomarker Discovery: Used as an internal standard in mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy for accurate quantification of metabolites in biological samples.
• Agrochemical Development: Preparation of isotopically labeled pesticides or herbicides to study environmental fate, degradation pathways, and residue analysis.
• Organic Synthesis: A versatile 13C-labeled synthon for constructing complex organic molecules, including heterocycles and natural product analogs, for mechanistic studies.
• Diagnostic Agent Production: Key precursor in the manufacturing of contrast agents or probes for advanced imaging techniques like Magnetic Resonance Spectroscopy (MRS).

Basic Information

Product Name	Mono-Ethyl Malonate-1,2,3-13C3
CAS No.	1189981-54-1
Molecular Formula	13C3H8O4
Molecular Weight	~136.09 g/mol (for 13C3)
Synonyms	Monoethyl Malonate-13C3; Ethyl Hydrogen Malonate-1,2,3-13C3; Malonic Acid Monoethyl Ester-13C3; 1,2,3-13C3-Monoethyl Malonate; Ethyl Hydrogen Propanedioate-13C3; 13C3-Monoethyl Malonate; Carbon-13 Labeled Monoethyl Malonate
EINECS	Contact for details

Quality Control

Our Mono-Ethyl Malonate-1,2,3-13C3 is produced under strict quality management systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to relevant standards for research chemicals and can provide material suitable for use in regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The product is compatible with strong alkali/organic solvents but should be kept away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% 13C3
Isotopic Purity (by MS)	≥ 98% M+3
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.