Description

Pantoprazole Sulfide-D7 (Major) is a deuterium-labeled isotopologue of a key intermediate in the synthesis of pantoprazole, a proton pump inhibitor. This high-purity compound is essential for pharmaceutical research and development, particularly in drug metabolism and pharmacokinetic (DMPK) studies. It is primarily used by analytical laboratories and pharmaceutical manufacturers for use as an internal standard in mass spectrometry, enabling precise quantification and ensuring regulatory compliance in bioanalytical methods.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS bioanalysis.
• Critical component in pharmacokinetic (PK) studies and drug metabolism research for pantoprazole and related compounds.
• Facilitates accurate quantification in clinical trial sample analysis, ensuring data integrity for regulatory submissions.
• Used in deuterium-labeling studies and stable isotope tracer experiments.
• Supports impurity profiling and characterization of pantoprazole drug substances and products.
• Valuable reference material for analytical method development and validation in compliance with ICH guidelines.

Basic Information

Product Name	Pantoprazole Sulfide-D7 (Major)
CAS No.	1189977-42-1
Molecular Formula	C16H8D7F2N3O4S
Molecular Weight	384.40 g/mol (approximate)
Synonyms	5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl-D7)methyl]sulfinyl]-1H-benzimidazole; Pantoprazole Sulfide-d7; 2-(((3,4-Dimethoxy-2-pyridinyl-D7)methyl)sulfinyl)-5-(difluoromethoxy)-1H-benzimidazole; Pantoprazole EP Impurity D-d7; Pantoprazole Related Compound D-d7; Pantoprazole Sulfide (Major) Deuterated; Pantoprazole-d7 Sulfide Intermediate
EINECS	Contact for details

Quality Control

Our Pantoprazole Sulfide-D7 (Major) is manufactured under controlled conditions to ensure exceptional isotopic purity and chemical integrity. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Mass Spectrometry, to confirm identity, chemical purity, and deuterium enrichment. Certificates of Analysis (COA) detailing all specifications are provided to support your GLP and GMP compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.