Description

Rac Epinephrine-D3 CAS NO 1189977-29-4 is a deuterium-labeled analog of the critical neurotransmitter and hormone epinephrine, serving as a vital internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers for applications in pharmacokinetics, metabolism studies, and quality control of drug substances.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the precise measurement of epinephrine levels in biological samples like plasma, serum, and urine.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for epinephrine and related compounds in preclinical and clinical research.
• Biomarker Analysis: Facilitates the sensitive and specific quantification of endogenous catecholamines in clinical diagnostics and research into neurological and cardiovascular conditions.
• Pharmaceutical Quality Control: Supports method development and validation for the assay and impurity profiling of epinephrine in active pharmaceutical ingredients (APIs) and finished drug products.
• Stable Isotope Dilution Assays: Critical for high-accuracy assays where the deuterated standard compensates for sample preparation losses and ionization variability in mass spectrometry.
• Forensic and Doping Control Analysis: Employed in confirmatory testing protocols to ensure the definitive identification and quantification of epinephrine and its metabolites.

Basic Information

Product Name	Rac Epinephrine-D3
CAS No.	1189977-29-4
Molecular Formula	C9H10D3NO3
Molecular Weight	186.23 g/mol
Synonyms	DL-Epinephrine-α,β,β-d3; (±)-Epinephrine-d3; Adrenaline-d3; 4-[1-Hydroxy-2-(methylamino)ethyl]benzene-1,2-diol-d3; 3,4-Dihydroxy-α-[(methylamino)methyl]benzyl alcohol-d3; Racemic Epinephrine-d3; 1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethanol-d3
EINECS	Contact for details

Quality Control

Our Rac Epinephrine-D3 is manufactured under strict quality management systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D
Chemical Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.