Description

3-Acetylthio-2-Methylpropanoic Acid-D5 is a deuterated analog of 3-acetylthio-2-methylpropanoic acid, a key intermediate in the synthesis of deuterium-labeled compounds. This stable isotope-labeled material is essential for creating internal standards used in quantitative mass spectrometry, ensuring high accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical chemistry facilities for applications in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• As a deuterated internal standard for the quantification of its non-labeled counterpart in biological matrices via LC-MS/MS.
• In the synthesis of deuterium-labeled drug metabolites for use in advanced pharmacokinetic and bioavailability studies.
• For tracer studies in metabolic pathway research and mechanistic investigations within pharmaceutical development.
• As a critical building block in the preparation of stable isotope-labeled active pharmaceutical ingredients (APIs) or related intermediates.
• Use in analytical method development and validation to meet stringent regulatory requirements for bioanalytical assays.
• Supporting forensic and environmental analysis where precise isotope dilution techniques are necessary.

Basic Information

Product Name	3-Acetylthio-2-Methylpropanoic Acid-D5
CAS No.	1189969-31-0
Molecular Formula	C7H7D5O3S
Molecular Weight	179.25 g/mol (approx.)
Synonyms	3-(Acetylthio)-2-methylpropanoic-2,2,3,3,3-d5 acid; 2-Methyl-3-sulfanylpropanoic-2,2,3,3,3-d5 acid acetate; Deuterated 3-Acetylthio-2-methylpropionic acid; 3-Acetylthio-2-methylpropanoic-d5 acid; ATMPA-d5; 3-(Acetylthio)-2-methylpropionic-d5 acid; [2H5]-3-Acetylthio-2-methylpropanoic Acid
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high chemical and isotopic purity, critical for analytical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and deuterium incorporation levels. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. We adhere to cGMP principles for the production of materials intended for pharmaceutical research support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.