Description

3,3,3-Trideuterio-1-(4-Methoxyphenyl)Propan-1-Ol is a deuterated derivative of 1-(4-methoxyphenyl)propan-1-ol, where three hydrogen atoms on the terminal methyl group are replaced with deuterium. This compound is a valuable stable isotope-labeled intermediate, offering enhanced metabolic stability and traceability in research applications. It is primarily utilized by pharmaceutical R&D and analytical laboratories for use as an internal standard in mass spectrometry, metabolic pathway studies, and the synthesis of deuterated drug candidates.

Application

• Pharmaceutical Research & Development: Serves as a key building block for synthesizing deuterated active pharmaceutical ingredients (APIs), where deuterium incorporation can improve pharmacokinetic profiles.
• Analytical Chemistry: Used as a high-purity internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for accurate quantification of its non-deuterated counterpart in complex matrices.
• Metabolite Tracing & Drug Metabolism Studies: Enables precise tracking of metabolic pathways and identification of metabolites due to the distinct mass shift provided by the deuterium atoms.
• Organic Synthesis Intermediate: Acts as a specialized chiral intermediate for the preparation of more complex, labeled organic molecules in academic and industrial research settings.
• Biochemical Probes: Employed in the development of probes for investigating enzyme mechanisms and biological processes where hydrogen/deuterium exchange is relevant.

Basic Information

Product Name	3,3,3-Trideuterio-1-(4-Methoxyphenyl)Propan-1-Ol
CAS No.	1189968-85-1
Molecular Formula	C10H11D3O2
Molecular Weight	169.23 g/mol
Synonyms	1-(4-Methoxyphenyl)-3,3,3-trideuterio-1-propanol; (4-Methoxyphenyl)(3,3,3-trideuteriopropyl)carbinol; 3,3,3-Trideuterio-1-(4-methoxyphenyl)-1-propanol; d3-1-(4-Methoxyphenyl)propan-1-ol; 1-(p-Methoxyphenyl)-3,3,3-trideuterio-1-propanol; Deuterated 4-Methoxyphenylpropyl alcohol; p-Methoxy-d3-benzenepropanol
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high isotopic purity and chemical purity suitable for sensitive analytical applications. Each batch is characterized by NMR (¹H, ²H) and mass spectrometry to confirm deuterium incorporation and identity. Certificates of Analysis (COA) detailing purity (by HPLC/GC), isotopic enrichment, and other relevant specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Isotopic Enrichment (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.