Description

7-Hydroxy Coumarin-13C3 is a stable isotope-labeled derivative of the naturally occurring phenolic compound umbelliferone. This product is specifically enriched with carbon-13 at three positions, making it an essential internal standard and tracer for advanced analytical and metabolic studies. It is primarily required by research institutions, pharmaceutical developers, and analytical laboratories engaged in quantitative mass spectrometry, pharmacokinetics, and drug metabolism research (DMPK).

Application

• Quantitative Analytical Standard: Serves as a critical internal standard for the precise quantification of 7-hydroxycoumarin and related metabolites in biological matrices using LC-MS/MS and GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Used as a stable isotope-labeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of coumarin-based compounds.
• Biochemical Research: Employed in enzymatic activity assays, particularly for studying cytochrome P450 enzymes like CYP2A6, where umbelliferone is a common fluorescent product.
• Pharmaceutical Reference Material: Acts as a certified reference material (CRM) for method development and validation in quality control laboratories to ensure accuracy and compliance.
• Isotope Dilution Mass Spectrometry (IDMS): Essential for high-accuracy measurements in clinical chemistry and environmental analysis to minimize matrix effects and improve data reliability.

Basic Information

Product Name	7-Hydroxy Coumarin-13C3
CAS No.	1189958-16-4
Molecular Formula	C613C3H6O3
Molecular Weight	165.12 g/mol (for 13C3 labeled form)
Synonyms	Umbelliferone-13C3; 7-Hydroxy-2H-1-benzopyran-2-one-13C3; Hydrangin-13C3; Skimmetin-13C3; 7-Hydroxycoumarin-13C3; 2H-1-Benzopyran-2-one, 7-hydroxy-13C3; β-Umbelliferone-13C3
EINECS	Contact for details

Quality Control

Every batch of our 7-Hydroxy Coumarin-13C3 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, verified by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific data on purity, isotopic purity (atom % 13C), and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C (on the labeled positions)
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.