Description

Betaxolol-D5 is a deuterium-labeled analog of the β-adrenergic receptor antagonist Betaxolol, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and forensic toxicology sectors who require precise quantification of Betaxolol.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the accurate measurement of Betaxolol in biological matrices.
• Pharmacokinetic Research: Used in drug metabolism and pharmacokinetic (DMPK) studies to track the absorption, distribution, metabolism, and excretion of Betaxolol.
• Bioanalytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Clinical Trial Support: Enables precise monitoring of drug concentration levels in plasma, serum, or urine during clinical trials for Betaxolol.
• Forensic and Toxicology Analysis: Assists in the definitive identification and quantification of Betaxolol in forensic investigations or overdose cases.
• Pharmaceutical Quality Control: Supports impurity profiling and assay validation for Betaxolol active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Betaxolol-D5
CAS No.	1189957-99-0
Molecular Formula	C18H24D5NO3
Molecular Weight	312.45 g/mol (approximate)
Synonyms	1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol-d5; (RS)-1-(4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)propan-2-ol-d5; Betaxolol (phenyl-d5); Betaxolol-d5 (deuterated); Betaxolol (phenyl ring-d5); Betaxolol (phenyl-D5); Deuterated Betaxolol Internal Standard
EINECS	Contact for details

Quality Control

Our Betaxolol-D5 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.