Description

1-[4-(1-Hydroxy-2-Methylpropan-2-Yl)Phenyl]-4-[4-[(2,3,4,5,6-Pentadeuteriophenyl)-Phenylmethoxy]Piperidin-1-Yl]Butan-1-One is a high-purity deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. This compound is specifically designed for use as a stable isotope-labeled internal standard in bioanalytical methods, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is an essential material for analytical chemists and researchers in pharmaceutical companies and CROs (Contract Research Organizations) who require definitive quantification and reliable data integrity for novel drug candidates.

Application

• Deuterated Internal Standard for LC-MS/MS: Primary application as a high-purity, isotopically labeled reference standard in Liquid Chromatography-Tandem Mass Spectrometry for quantitative bioanalysis.
• Pharmaceutical R&D: Critical for method development and validation in the study of drug metabolism and pharmacokinetics (DMPK) of related active pharmaceutical ingredients (APIs).
• Metabolite Identification: Used to track and identify drug metabolites in complex biological matrices with high specificity.
• Preclinical and Clinical Trials: Supports regulatory submissions by providing robust analytical data for safety and efficacy studies.
• Chemical Reference Material: Serves as a certified reference material for quality control laboratories ensuring analytical method accuracy.

Basic Information

Product Name	1-[4-(1-Hydroxy-2-Methylpropan-2-Yl)Phenyl]-4-[4-[(2,3,4,5,6-Pentadeuteriophenyl)-Phenylmethoxy]Piperidin-1-Yl]Butan-1-One
CAS No.	1189954-07-1
Molecular Formula	C32H39D5O3
Molecular Weight	~479.71 g/mol
Synonyms	Deuterated Fexofenadine Related Compound; 1-[4-(1-Hydroxy-2-methylpropan-2-yl)phenyl]-4-[4-[(2,3,4,5,6-pentadeuteriophenyl)(phenyl)methoxy]piperidin-1-yl]butan-1-one; Fexofenadine-d5 Impurity/Intermediate; [D5]-1-[4-(1-Hydroxy-2-methylpropan-2-yl)phenyl]-4-[4-[bis(phenyl-d5)methoxy]piperidin-1-yl]butan-1-one; ALX 540-100-d5 derivative; Isotopically Labeled Piperidine Butanone Derivative; Deuterated Benzhydryl Ether Intermediate
EINECS	Contact for details

Quality Control

Every batch of this deuterated intermediate is produced and analyzed under strict cGMP (current Good Manufacturing Practice) guidelines to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for assay, isotopic purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.