Description

Promethazine-D6 Hydrochloride Salt is a high-purity, isotopically labeled internal standard critical for ensuring analytical accuracy and reliability in quantitative mass spectrometry. This deuterated compound is essential for researchers and quality control laboratories requiring precise measurement and validation of promethazine and its metabolites. It is primarily utilized in pharmaceutical research, forensic toxicology, and clinical diagnostics for method development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS and GC-MS quantification of promethazine in biological matrices (e.g., plasma, urine).
• Method Development and Validation in pharmaceutical bioanalysis and pharmacokinetic studies.
• Forensic and Clinical Toxicology for the accurate determination of promethazine in drug screening and overdose cases.
• Metabolite Tracing and Stable Isotope Dilution Assays in drug metabolism and disposition (DMPK) research.
• Quality Control and Assurance in pharmaceutical manufacturing for impurity profiling and assay standardization.
• Reference Material for calibrating analytical instruments and ensuring data integrity in GLP/GMP environments.

Basic Information

Product Name	Promethazine-D6 Hydrochloride Salt
CAS No.	1189947-02-1
Molecular Formula	C17H14D6ClN2S • HCl
Molecular Weight	329.31 g/mol (approx.)
Synonyms	Promethazine-d6 HCl; Deuterated Promethazine Hydrochloride; (2R)-N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine-d6 Hydrochloride; 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, hydrochloride-d6; (±)-Promethazine-d6 Hydrochloride; Promethazine (phenyl-d5, methyl-d) Hydrochloride; Internal Standard Promethazine-d6
EINECS	Contact for details

Quality Control

Every batch of Promethazine-D6 Hydrochloride Salt is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Comprehensive testing includes isotopic enrichment (D6) by NMR and MS, chemical purity by HPLC, and confirmation of structure. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.