Description

Diglyme-D6 is a deuterated analog of diethylene glycol dimethyl ether, where all hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This high isotopic purity makes it an invaluable non-reactive solvent and chemical shift reference standard for advanced analytical techniques, particularly Nuclear Magnetic Resonance (NMR) spectroscopy. It is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and specialty chemical industries where precise molecular structure elucidation and reaction monitoring are critical.

Application

• NMR Spectroscopy Solvent: Primary application as an inert, deuterated solvent for proton (¹H) and carbon-13 (¹³C) NMR analysis, providing a lock signal and minimizing solvent interference.
• Chemical Shift Reference: Serves as an internal standard for calibrating chemical shifts in NMR spectra due to its well-defined, consistent signal.
• Reaction Mechanism Studies: Used as a solvent in kinetic and mechanistic studies where proton exchange must be minimized to track deuterium labeling.
• Pharmaceutical R&D: Employed in the synthesis and analysis of deuterated drug compounds (deuterated active pharmaceutical ingredients).
• Polymer Chemistry Research: Acts as a solvent for anionic polymerization and other sensitive reactions requiring anhydrous, aprotic conditions.
• Electrolyte Component: Potential use as a component in specialized electrolyte formulations for lithium-ion battery research.

Basic Information

Product Name	Diglyme-D6
CAS No.	1189942-73-1
Molecular Formula	C6D14O3
Molecular Weight	138.26 g/mol
Synonyms	Bis(2-methoxyethyl) ether-d14; Diethylene glycol dimethyl ether-d14; 2,5,8,11-Tetraoxadodecane-d14; Deuterated diglyme; DME-D6 (ambiguous, avoid); DEGDME-d14; [D14]-Diglyme; 1,2-Bis(2-methoxyethoxy)ethane-d14
EINECS	Contact for details

Quality Control

Our Diglyme-D6 is produced and handled under strict quality protocols to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is analyzed to confirm deuterium enrichment (typically ≥99.5 atom % D) and the absence of protonated impurities. A comprehensive Certificate of Analysis (COA) detailing NMR purity, chemical purity (by GC), water content (by Karl Fischer titration), and specific parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers should be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent absorption of atmospheric moisture and CO2.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Deuterium Content (NMR)	≥ 99.5 atom % D
Purity (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Protonated Impurity (¹H NMR)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.