Description

1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethanol is a deuterium-labeled derivative of a key pyridine-ethanol intermediate, offering a stable isotopic label for advanced research and development. This compound is critical for applications requiring precise metabolic and pharmacokinetic studies, where tracking molecular pathways is essential. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers in the synthesis of deuterated active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block for incorporating deuterium into drug molecules to enhance metabolic stability and pharmacokinetic profiles.
• Metabolic Pathway Tracing: Used as a stable isotopic tracer in mass spectrometry-based studies to investigate drug metabolism and disposition.
• Pharmaceutical Research & Development: Enables the development of novel deuterium-labeled drug candidates for improved efficacy and safety.
• Fine Chemical Manufacturing: Acts as a specialized intermediate for producing high-value deuterated compounds for research and industrial applications.
• Contract Research Organization (CRO) Services: Supplied to CROs conducting advanced bioanalytical and DMPK (Drug Metabolism and Pharmacokinetics) studies.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and isotopic labeling techniques.

Basic Information

Product Name	1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethanol
CAS No.	1189935-46-3
Molecular Formula	C11H11D4NO3
Molecular Weight	213.27 g/mol
Synonyms	2-[5-(2-Methyl-1,3-dioxolan-2-yl)pyridin-2-yl]ethan-1,1,2,2-d4-ol; Deuterated 2-(5-(2-Methyl-1,3-dioxolan-2-yl)pyridin-2-yl)ethanol; 2-(5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridyl)ethanol-d4; 2-[5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridyl]ethan-1,1,2,2-d4-ol; 1,1,2,2-Tetradeuterio-2-(5-(2-methyl-1,3-dioxolan-2-yl)pyridin-2-yl)ethanol; CAS 1189935-46-3
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under strict quality systems to ensure batch-to-batch consistency and isotopic purity. Each lot of 1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethanol undergoes comprehensive analytical testing, including NMR (¹H, ²H, ¹³C), HPLC, and mass spectrometry, to confirm chemical and isotopic identity, purity, and absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (¹H, ¹³C, ²H)
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.