Description

1,1,2,3,3-Pentadeuterio-1-[4-(1-Hydroxy-2-Methoxyethyl)Phenoxy]-3-(Propan-2-Ylamino)Propan-2-Ol is a deuterated derivative of a β-adrenergic receptor ligand, offering a stable isotopic label for advanced research and analytical applications. This compound is critical for use as an internal standard in mass spectrometry, enabling precise quantification and reducing matrix effects in complex biological samples. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of its non-deuterated counterpart in bioanalytical assays for drug development.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds.
• Stable Isotope Labeling: Serves as a labeled analog in proteomics and metabolomics research to facilitate relative and absolute quantification.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradation products.
• Clinical Research: Supports the development and validation of diagnostic assays requiring high specificity and sensitivity.
• Reference Standard: Provides a certified material for calibrating analytical instruments and ensuring method accuracy in quality control laboratories.

Basic Information

Product Name	1,1,2,3,3-Pentadeuterio-1-[4-(1-Hydroxy-2-Methoxyethyl)Phenoxy]-3-(Propan-2-Ylamino)Propan-2-Ol
CAS No.	1189934-03-9
Molecular Formula	C15D5H20NO4
Molecular Weight	Contact for details
Synonyms	Deuterated Carvedilol-d5; 1,1,2,3,3-Pentadeutero-1-[4-(1-Hydroxy-2-Methoxyethyl)Phenoxy]-3-[(1-Methylethyl)Amino]-2-Propanol; 3-(Propan-2-ylamino)-1-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-1,1,2,3,3-pentadeuteriopropan-2-ol; Carvedilol D5; Carvedilol-d5; (RS)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d5; (±)-Carvedilol-d5
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D-content), chemical purity, and chromatographic profile. We support compliance with cGMP and ISO 9001 standards for research and regulatory submission purposes. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.