Description

Trimebutine-D5 is a deuterated internal standard of the pharmaceutical compound trimebutine, specifically designed for analytical and research applications. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for method development, validation, and pharmacokinetic studies. The compound's stable isotopic label provides a critical reference point for precise measurement of its non-deuterated counterpart in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of trimebutine in plasma, serum, and other biological samples.
• Pharmacokinetic & Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track drug levels and understand metabolic pathways.
• Pharmaceutical Quality Control: Enables precise assay and impurity profiling of trimebutine active pharmaceutical ingredients (APIs) and finished drug products.
• Clinical Research: Supports clinical trial sample analysis to determine drug concentration-time profiles in patients.
• Forensic & Doping Control: Applied in specialized testing laboratories for the confirmatory analysis of trimebutine.
• Method Development & Validation: A critical tool for developing robust, sensitive, and specific analytical methods compliant with ICH and FDA guidelines.

Basic Information

Product Name	Trimebutine-D5
CAS No.	1189928-38-8
Molecular Formula	C22H26D5NO5
Molecular Weight	Approx. 392.52 g/mol
Synonyms	Trimebutine-d5; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate-d5; 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester-d5; (±)-Trimebutine-d5; DL-Trimebutine-d5; Deudrated Trimebutine; Trimebutine Internal Standard; Trimebutine IS
EINECS	Contact for details

Quality Control

Every batch of Trimebutine-D5 is manufactured and analyzed under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm chemical structure, isotopic purity (>98 atom % D), and chemical purity. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to relevant standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the material should be handled in a dry environment and the container kept tightly sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.