Description

Thioridazine-D3 Hydrochloride is a stable isotope-labeled analog of the antipsychotic agent Thioridazine, where three hydrogen atoms are replaced by deuterium. This high-purity reference standard is critical for ensuring accuracy and reliability in quantitative analytical methods. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and quality control of active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering reference for the precise quantification of Thioridazine and its metabolites in complex biological matrices like plasma and serum.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used as a key component in developing robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Drug Impurity Profiling and Stability Testing: Assists in identifying and quantifying potential degradants or process-related impurities in pharmaceutical formulations.
• Forensic and Clinical Toxicology: Supports accurate measurement of Thioridazine levels in forensic investigations or therapeutic drug monitoring (TDM).
• Isotope Dilution Mass Spectrometry (IDMS): Provides the highest level of measurement accuracy in definitive quantitative analysis.

Basic Information

Product Name	Thioridazine-D3 Hydrochloride
CAS No.	1189928-36-6
Molecular Formula	C21H23D3N2S2•HCl
Molecular Weight	407.06 g/mol (approx.)
Synonyms	10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-(methylthio)-10H-phenothiazine-3,7,8-d3 Hydrochloride; Thioridazine-d3 HCl; Deuterated Thioridazine Hydrochloride; Mellaril-d3 Hydrochloride; 2-Methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine-d3 Hydrochloride; Thioridazine (phenyl-d3) Hydrochloride; Stable Isotope Labeled Thioridazine HCl
EINECS	Contact for details

Quality Control

Every batch of Thioridazine-D3 Hydrochloride is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing critical parameters such as isotopic purity, chemical purity, and absence of interfering unlabeled compound. Our quality commitment ensures compliance with the standards expected for high-value reference materials in pharmaceutical analysis.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥99.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.