Description

2-Butyl-D3-4-Chloro-1H-Imidazole-5-Carboxaldehyde is a high-purity, deuterated building block of significant value in advanced pharmaceutical research and development. This compound matters because its deuterium-labeled structure is specifically designed to alter metabolic pathways, enhancing the pharmacokinetic profiles of drug candidates. It is primarily needed by medicinal chemists and process development scientists within the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical deuterated synthon for the development of new chemical entities (NCEs) with improved metabolic stability and reduced toxicity profiles.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify the fate of molecules in biological systems.
• Agrochemical Research: Serves as a key precursor in the synthesis of novel, high-performance crop protection agents and herbicides.
• Isotope Labeling: Essential for creating isotopically labeled standards used in analytical methods like LC-MS for accurate quantification in complex matrices.
• Chemical Biology Probe Development: Utilized in the design of molecular probes to study enzyme mechanisms and biological pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable synthesis of deuterated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Butyl-D3-4-Chloro-1H-Imidazole-5-Carboxaldehyde
CAS No.	1189927-81-8
Molecular Formula	C8H8D3ClN2O
Molecular Weight	189.67 g/mol
Synonyms	4-Chloro-2-(butyl-d3)-1H-imidazole-5-carboxaldehyde; 2-(Butyl-d3)-4-chloro-1H-imidazole-5-carbaldehyde; 4-Chloro-2-(1,1,1-trideuteriobutyl)-1H-imidazole-5-carbaldehyde; Deuterated 2-Butyl-4-chloroimidazole-5-carboxaldehyde; 2-n-Butyl-d3-4-chloroimidazole-5-carboxaldehyde; 1189927-81-8; (2-Butyl-4-chloro-1H-imidazol-5-yl)methan-d-aldehyde
EINECS	Contact for details

Quality Control

Our 2-Butyl-D3-4-Chloro-1H-Imidazole-5-Carboxaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and LC-MS, to confirm chemical identity, isotopic enrichment (D3), and purity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3, LC-MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.