Description

2-Methoxy-5-[3,3,3-Trideuterio-2-[2-(2-Ethoxyphenoxy)Ethylamino]Propyl]Benzenesulfonamide:Hydrochloride is a deuterated sulfonamide derivative, specifically designed for advanced research and development applications where isotopic labeling is critical. This compound, with CAS number 1189923-88-3, is valued for its role as a stable isotope-labeled internal standard or a key intermediate in the synthesis of more complex labeled molecules. It is primarily utilized by pharmaceutical and biotechnology research organizations focused on drug metabolism and pharmacokinetics (DMPK) studies, analytical method development, and the synthesis of novel therapeutic agents.

Application

• As a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical methods (LC-MS/MS).
• As a key deuterated intermediate in the synthesis of more complex drug candidates or metabolites for pharmaceutical R&D.
• In drug metabolism and pharmacokinetics (DMPK) studies to investigate absorption, distribution, metabolism, and excretion pathways.
• For use in analytical method development and validation to ensure accuracy, precision, and regulatory compliance.
• In mechanistic studies within medicinal chemistry to understand reaction pathways or biological interactions.
• As a high-purity reference material for quality control laboratories in the pharmaceutical industry.

Basic Information

Product Name	2-Methoxy-5-[3,3,3-Trideuterio-2-[2-(2-Ethoxyphenoxy)Ethylamino]Propyl]Benzenesulfonamide:Hydrochloride
CAS No.	1189923-88-3
Molecular Formula	C20H28D3N2O5S·HCl
Molecular Weight	469.03 g/mol (for monoisotopic mass)
Synonyms	2-Methoxy-5-[3,3,3-trideuterio-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]benzenesulfonamide hydrochloride; Deuterated Carvedilol Metabolite Derivative; 2-Methoxy-5-[(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl-3,3,3-d3)]benzenesulfonamide hydrochloride; d3-Labeled Sulfonamide Hydrochloride; Benzenesulfonamide, 2-methoxy-5-[3,3,3-trideuterio-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-, hydrochloride; Carvedilol deuterated analog hydrochloride
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high chemical and isotopic purity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing purity, isotopic enrichment, and other critical specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can compromise stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.