Description

n-(4-Amino-6,7-Dimethoxyquinazol-2-Yl)-n-Methyl-D3-Propylenediamine CAS NO 1189922-32-4 is a deuterated derivative of a quinazoline-based compound, serving as a critical stable isotope-labeled intermediate. This product matters for its role in enabling advanced research and development, particularly in the fields of pharmaceutical discovery and metabolic studies, by providing a non-radioactive isotopic tracer. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in the synthesis of deuterated drug candidates, pharmacokinetic analysis, and the development of novel therapeutic agents.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: As a key building block for incorporating deuterium into potential drug molecules to alter metabolic profiles.
• Metabolic Pathway Tracing: Used in mass spectrometry-based studies to track the absorption, distribution, metabolism, and excretion (ADME) of compounds.
• Internal Standard Development: Essential for creating accurate and reliable quantitative analytical methods, such as LC-MS/MS, in bioanalytical laboratories.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by investigating the deuterium isotope effect on biological activity.
• Preclinical and Clinical Trial Support: Provides labeled materials necessary for conducting definitive metabolism and safety studies required for regulatory submissions.
• Isotope-Labeled Reference Standard Production: Serves as a precursor for certified reference materials used in quality control and method validation.

Basic Information

Product Name	n-(4-Amino-6,7-Dimethoxyquinazol-2-Yl)-n-Methyl-D3-Propylenediamine
CAS No.	1189922-32-4
Molecular Formula	C₁₄H₁₉D₃N₆O₂
Molecular Weight	305.38 g/mol
Synonyms	N-Methyl-D3-1,3-propanediamine, N-(4-amino-6,7-dimethoxy-2-quinazolinyl)-; 1,3-Propanediamine, N-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-methyl-3,3,3-d3-; Deuterated Doxazosin Impurity/Intermediate; D3-Labeled Quinazoline Derivative; 4-Amino-6,7-dimethoxy-2-[(3-methylamino-3,3,3-trideuteropropyl)amino]quinazoline; N-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-methyl-1,3-propanediamine-d3
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under strict quality management to ensure isotopic purity and chemical integrity, which are paramount for research accuracy. Each batch is characterized using advanced analytical techniques including NMR (for deuterium incorporation), HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing assay, isotopic enrichment, and impurity profiles. We support compliance with relevant guidelines for materials used in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.