Description

n-(Phenylacetyl-D5)Glycine is a stable isotope-labeled analog of phenylacetyl glycine, where five hydrogen atoms on the phenylacetyl moiety are replaced with deuterium (D). This high-purity compound is specifically engineered for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors, particularly for metabolic studies and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of phenylacetyl glycine and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Biomarker Research: Enables accurate tracking and measurement of phenylacetyl glycine levels in studies of metabolic disorders, gut microbiome activity, and liver function.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for high-fidelity pharmacokinetic profiling, absorption, distribution, metabolism, and excretion (ADME) studies of pharmaceutical compounds.
• Clinical Diagnostics: Used in the development and validation of diagnostic assays for inborn errors of metabolism and other conditions where phenylacetyl glycine is a relevant biomarker.
• Stable Isotope Labeling: Serves as a key building block or reference material in the synthesis of other deuterated compounds for research purposes.
• Quality Control & Method Validation: Provides a reliable reference point for ensuring the accuracy, precision, and reproducibility of analytical methods in regulated environments.

Basic Information

Product Name	n-(Phenylacetyl-D5)Glycine
CAS No.	1189920-31-7
Molecular Formula	C10H6D5NO3
Molecular Weight	199.22 g/mol (for C10H6D5NO3)
Synonyms	Glycine, N-[(2,3,4,5,6-pentadeuteriophenyl)acetyl]-; N-(Phenylacetyl-2,3,4,5,6-d5)glycine; Phenylacetyl-d5 Glycine; Deuterated Phenylacetylglycine; 2-[(2,3,4,5,6-Pentadeuteriophenyl)acetamido]acetic Acid; Hippuric Acid-d5 (amide-deuterated); N-(2,3,4,5,6-Pentadeuteriobenzoyl)glycine (common misnomer for acetyl form); PA-d5-Gly
EINECS	Contact for details

Quality Control

Our n-(Phenylacetyl-D5)Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm chemical identity, isotopic purity (atom % D), and chemical purity. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure full traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.