Description

Ethyl 2-Oxo-4-Phenylbutyrate D5 is a high-purity, deuterium-labeled analog of ethyl 2-oxo-4-phenylbutyrate, serving as a critical stable isotope-labeled internal standard for precise quantitative analysis. This compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of ethyl 2-oxo-4-phenylbutyrate and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Research: Critical in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of parent drug compounds.
• Bioanalytical Method Development: Enables the development and validation of highly specific and sensitive analytical methods in compliance with FDA and ICH guidelines.
• Metabolite Identification: Aids in the structural elucidation and quantification of drug metabolites using high-resolution mass spectrometry.
• Clinical Trial Support: Provides reliable data for bioequivalence and therapeutic drug monitoring studies during clinical phases.
• Quality Control in API Synthesis: Can be utilized as a reference standard to monitor the synthesis and purity of the non-deuterated active pharmaceutical ingredient (API).

Basic Information

Product Name	Ethyl 2-Oxo-4-Phenylbutyrate D5
CAS No.	1189911-53-2
Molecular Formula	C12H8D5O3
Molecular Weight	~209.25 g/mol
Synonyms	Ethyl 2-Oxo-4-phenylbutyrate-d5; Ethyl 4-Phenyl-2-oxobutyrate-d5; Ethyl (4-Phenyl-2-oxobutanoate)-d5; Deuterated Ethyl 2-Oxo-4-phenylbutyrate; Ethyl 2-Keto-4-phenylbutyrate D5; Ethyl α-Ketobenzenebutanoate-d5; Ethyl 4-Phenyl-2-oxobutanoate-d5; Ethyl 2-Oxo-4-phenylbutanoate-d5
EINECS	Contact for details

Quality Control

Our Ethyl 2-Oxo-4-Phenylbutyrate D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by NMR or MS), and residual solvent content. We adhere to relevant industry standards for reference materials, and custom purity grades or specific isotopic enrichment levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.