Description

Acetazolamide-D3 CAS NO 1189904-01-5 is a deuterium-labeled analog of the carbonic anhydrase inhibitor acetazolamide, where three hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity, non-interfering internal standard for the precise quantification of acetazolamide in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic and pharmacodynamic research to track the absorption, distribution, metabolism, and excretion of acetazolamide with high specificity.
• Bioanalytical Method Development & Validation: Critical for developing and validating robust, regulatory-compliant (FDA, EMA) analytical methods in support of clinical trials and non-clinical studies.
• Therapeutic Drug Monitoring (TDM): Enables accurate measurement of drug concentrations in patient samples to optimize dosing regimens for conditions like glaucoma, epilepsy, and altitude sickness.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the labeled spike in IDMS, the gold-standard technique for achieving highest accuracy in quantitative analysis.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or related substances in drug substance and product analysis.

Basic Information

Item	Detail
Product Name	Acetazolamide-D3
CAS No.	1189904-01-5
Molecular Formula	C4D3H2N4O3S2
Molecular Weight	225.26 g/mol (for C4D3H2N4O3S2)
Synonyms	Acetazolamide-d3; 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide-d3; N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide-d3; 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide-d3; Diamox-d3; Deuterated Acetazolamide; Acetazolamide (phenyl-d3); Acetazolamide Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Acetazolamide-D3 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting requirements of quantitative bioanalysis. Our quality assurance includes comprehensive characterization by NMR, MS, and HPLC to confirm structure, isotopic enrichment, and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Production can be aligned with cGMP guidelines for applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.