Description

1-(5-Oxophenothiazin-10-Yl)-N,n-Bis(Trideuteriomethyl)Propan-2-Amine is a deuterated derivative of a phenothiazine-based compound, offering enhanced metabolic stability and traceability for advanced research applications. This high-value specialty chemical is critical for scientists requiring precise isotopic labeling in pharmacokinetic and metabolic studies. It serves as a key intermediate or reference standard for pharmaceutical R&D, particularly in the development and analysis of central nervous system (CNS) active agents and other therapeutic compounds.

Application

• Pharmaceutical Reference Standard: Used as an internal standard in quantitative bioanalytical methods like LC-MS for accurate drug metabolite profiling.
• Deuterated Drug Intermediate: Serves as a building block in the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) to improve drug metabolism and pharmacokinetics (DMPK).
• Metabolic Pathway Tracing: Enables detailed studies of drug absorption, distribution, metabolism, and excretion (ADME) due to its isotopic label.
• Neuroscience Research: Applied in the investigation of phenothiazine-derived compounds and their interactions with biological targets relevant to neurological conditions.
• Stable Isotope Labeling: Utilized in proteomics and metabolomics research as a tracer to understand complex biological mechanisms.
• Process Chemistry & Impurity Characterization: Acts as a marker or standard for identifying and quantifying process-related impurities in API manufacturing.

Basic Information

Product Name	1-(5-Oxophenothiazin-10-Yl)-N,n-Bis(Trideuteriomethyl)Propan-2-Amine
CAS No.	1189892-93-0
Molecular Formula	C19H18D6N2OS
Molecular Weight	~346.53 g/mol
Synonyms	10-[3-[Bis(trideuteriomethyl)amino]-2-propyl]-5H-phenothiazin-5-one; N,N-Bis(trideuteriomethyl)-1-(5-oxo-5H-phenothiazin-10-yl)propan-2-amine; Deuterated Promazine Sulfoxide Derivative; 1-(5-Oxo-10H-phenothiazin-10-yl)-N,N-bis(trideuteriomethyl)-2-propanamine; d6-Labeled Phenothiazine Ketone; 1189892-93-0; 10-(3-(Bis(trideuteriomethyl)amino)-2-propyl)phenothiazin-5-one
EINECS	Contact for details

Quality Control

Our 1-(5-Oxophenothiazin-10-Yl)-N,n-Bis(Trideuteriomethyl)Propan-2-Amine is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and identity are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isotopic Purity (d6)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.