Description

2-Hydroxy-4-Phenylbutyric Acid, Ethyl Ester-D5 is a deuterated derivative of a key chiral building block, where five hydrogen atoms are replaced with deuterium, offering enhanced metabolic stability and utility as an internal standard in analytical chemistry. This high-purity labeled compound is critical for pharmaceutical research and development, particularly in pharmacokinetic and metabolic studies where precise quantification is required. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in advanced drug discovery and development processes.

Application

• Pharmaceutical Research: Serves as a stable isotope-labeled internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods using LC-MS/MS.
• Metabolic Studies: Used in drug metabolism and pharmacokinetics (DMPK) research to trace metabolic pathways and improve the reliability of analytical data.
• Chiral Intermediate Synthesis: Acts as a deuterated chiral synthon for the preparation of more complex labeled pharmaceutical compounds and active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Provides a certified reference material for method development, validation, and quality control in regulatory-compliant laboratories.
• Isotope Dilution Mass Spectrometry (IDMS): Essential for high-precision quantitative analysis, ensuring superior accuracy and reproducibility in trace-level detection.

Basic Information

Product Name	2-Hydroxy-4-Phenylbutyric Acid, Ethyl Ester-D5
CAS No.	1189892-05-4
Molecular Formula	C12D5H11O3
Molecular Weight	~211.27 g/mol
Synonyms	Ethyl 2-Hydroxy-4-phenylbutyrate-d5; Ethyl (2R/S)-2-Hydroxy-4-phenylbutanoate-d5; 2-Hydroxy-4-phenylbutanoic Acid Ethyl Ester-d5; HPG-d5 Ethyl Ester; Deuterated Ethyl 2-Hydroxy-4-phenylbutyrate; (RS)-2-Hydroxy-4-phenylbutyric Acid Ethyl Ester-d5; Ethyl 4-Phenyl-2-hydroxybutyrate-d5; Ethyl O-Desmethylphenibut-d5
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-Phenylbutyric Acid, Ethyl Ester-D5 is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.